It was the second game in the 2022 World Qualifier for both countries with Ghana hopeful of at least returning to Accra with a point.
Prior to the crucial encounter, South Africa had a played a stalemate with Zimbabwe while Ghana had defeated Ethiopia in the first group games.
It was a do and die affair as both countries needed the points at all cost to boost chances of qualifying from the group stages of the qualifiers.
Ghana had missed top stars like Jordan Ayew, Abdul Baba Rahman, Jeffery Schulpp, Kamaldeen Suleiman, Andy Yiadom all to coronavirus restrictions but coach CK Akonnor managed to parade the best of squad for the crucial showdown against the South Africans.
Debutante like Hearts of Oak skipper Fatawu Mohammed was handed a starting berth at the right-back position because Andy Yiadom had returned to England due to covid restrictions.
Ghana was super in the first half despite failing to find the back of the net with skipper Andre Ayew and Joel Fameyeh missing out on some glaring opportunities.
Percy Tau and his South African teammates also came in very strong to make a case for themselves but the dirty forty-five minutes of the game ended goalless.
The two countries returned from the tunnel with coach Hugo Bruce side showing dominance even though Ghana was able to sustain the pressure from the Bafana Bafana.
Unfortunately for Ghana, goalkeeper Richard Ofori had to be substituted for Lawrence Ati Zigi after picking up an injury.
As if Ghana was returning to Accra with a point, out of nowhere Bongokuhle Hlongwane broke the deadlock of the game for South Africa in the 83rd minute.
Coach CK Akonnor and his charges kept pressurizing the South Africans for the equalizer but all efforts went fruitless as the game ended 1:0 in favor of the South Africans.
The victory therefore means South Africa lead the group with four points after two matches while Ghana has only three placing second.